The series follows the life of Meredith Grey (Ellen Pompeo), the daughter of world renowned general surgeon Ellis Grey (Kate Burton), starting from her acceptance into the surgical residency program at the fictional Seattle Grace Hospital (later named Seattle Grace Mercy West and finally, Grey Sloan Memorial Hospital). During her time as an intern, Grey works alongside fellow physicians Cristina Yang (Sandra Oh), Izzie Stevens (Katherine Heigl), Alex Karev (Justin Chambers) and George O'Malley (T. R. Knight), who each struggle to balance their personal lives with hectic schedules and stressful residency requirements. During their internship, they are overseen by Miranda Bailey (Chandra Wilson), a senior resident, who works with attending physicians Derek Shepherd (Patrick Dempsey), head of neurosurgery and who also happens to be Meredith's love interest, and Preston Burke (Isaiah Washington), head of cardiothoracic surgery, who becomes Yang's fiancé. Richard Webber (James Pickens Jr.), Chief of Surgery and attending general surgeon, is the former lover of Ellis Grey. During the first six seasons, Burke, O'Malley, and Stevens all depart the series.
The series also shows drama and emotions focused on Meredith's life. In addition to Webber, Burke, and Shepherd, the surgical wing is primarily supervised by Addison Montgomery (Kate Walsh), Shepherd's ex-wife and the head of OB/GYN, neonatal and fetal surgery who leaves for Los Angeles at the end of season 3; Mark Sloan (Eric Dane), head of plastic surgery and also certified in ENT surgery; Callie Torres (Sara Ramirez), a resident who later becomes head of orthopedic surgery and leaves Seattle for New York at the end of the 12th season; Erica Hahn (Brooke Smith), as head of cardiothoracic surgery, who leaves Seattle Grace in season 5 after a disagreement with Torres; Owen Hunt (Kevin McKidd), as head of trauma surgery who later marries and divorces Yang; Arizona Robbins (Jessica Capshaw), as head of pediatric surgery, and later head of maternal / fetal surgery who marries Torres; Teddy Altman (Kim Raver), as head of cardiothoracic surgery who departs at the end of season 8 but returns in season 14; and Amelia Shepherd (Caterina Scorsone), Derek's sister, who is hired to replace him as head of neurosurgery.
Lexie Grey (Chyler Leigh), Meredith's paternal half-sister, joins the residency program in season 4 until her death with her love interest Mark Sloan in a plane crash at the end of season 8, after which Seattle Grace is renamed Grey Sloan Memorial Hospital in their memory. Former Mercy-West residents April Kepner (Sarah Drew) and Jackson Avery (Jesse Williams) join Seattle Grace following a hospital merger in season 6. Other additions include Leah Murphy (Tessa Ferrer), who departs at the end of season 10 but returns during season 13; Shane Ross (Gaius Charles), who leaves with Yang for Zürich, Switzerland, in the season 10 finale; Stephanie Edwards (Jerrika Hinton), who resigns at the end of season 13; Jo Wilson (Camilla Luddington), who marries Karev; Andrew DeLuca (Giacomo Gianniotti), the former love interest of Meredith's maternal half sister Maggie Pierce(Kelly McCreary) who also served as head of cardiothoracic surgery; and Ben Warren (Jason George), an anesthesiologist-turned resident-turned firefighter who marries Bailey. Season 11 sees the death of Derek Shepherd, and in season 12, attending cardiovascular surgeon Nathan Riggs (Martin Henderson) joins the show, and later briefly becomes Meredith's love interest. In the early episodes of season 14, Thomas Koracick (Greg Germann), an attending neurosurgeon, begins making appearances and Riggs leaves the series to start a life with Owen's long-lost sister Megan (Abigail Spencer); by the season finale, Robbins, Kepner and Warren also depart the show. Midway through the 16th season, Cormac Hayes (Richard Flood) becomes the new chief of pediatric surgery and Karev departs to reunite with Stevens. During the 17th season, DeLuca is stabbed while chasing a child abductor/ human trafficker and despite the efforts of Hunt and Altman, he dies. Avery and Koracick also depart in season 17, with Avery moving to Boston to take over his family's charitable foundation and Koracick leaving to assist him. In Season 18, Hayes moves back to his home country, Hunt and Altman flee the country, Marsh returns to Minnesota, Webber and Fox go on sabbatical, and Bailey resigns as chief of surgery, leaving Grey as chief of surgery. In Season 19, new interns Simone Griffith (Alexis Floyd), Benson "Blue" Kwan (Harry Shum Jr.), Jules Millin (Adelaide Kane), Mika Yasuda (Midori Francis) and Lucas Adams (Niko Terho), Derek and Amelia's nephew, join the program; Meredith moves to Boston and Pierce departs to move to Chicago. In Season 20, Marsh resigns from his role as Residency Director and moves to Boston with Meredith; leaving Bailey to be the new Residency Director.
Meredith Grey, the daughter of the once-renowned surgeon Ellis Grey, becomes an intern at the Seattle Grace Hospital. She meets fellow interns Cristina Yang, Isobel "Izzie" Stevens, George O'Malley and Alex Karev who become her closest friends during the intern program. She finds herself working with renowned surgeons such as the heart surgeon Preston Burke and Richard Webber, chief of surgery and old friend of her mother. She finds herself working under her one night stand and famous neurosurgeon Derek Shepherd and working with her resident Dr. Miranda Bailey also known as The Nazi.
Season 2[]
Life gets even more intense for the doctors and interns of Seattle Grace Hospital in year two as Meredith and Derek's relationship goes from odd to downright insane with the arrival of Derek's wife, and Alex lets his Izzie obsession out of the bag.
Season 3[]
They are doctors, lovers, and friends. Join the staff of Seattle Grace Hospital as they learn there are no easy cures for life’s challenges and that each choice comes in shades of gray.
Season 4[]
Enter a world of change in the irresistible and unforgettable fourth season of Grey's Anatomy. Love, lies, and family ties are revealed as the surgeons of Seattle Grace discover that their choices have major unintended consequences. And coupled with the arrival of some very eager new interns, life at the hospital sizzles with more emotion, excitement, and heartbreak than ever before.
Season 5[]
Live for the moment. Dive deeper into the lives and loves of "Grey's Anatomy"! The doctors struggle and thrive as they enter uncharted territories of life. Discover what happens in the on-again, off-again world of Derek and Meredith, and witness the budding relationship between Cristina and Owen, Seattle Grace's newest doctor.
Season 6[]
Expect more competition, more doctors, and much more drama as Seattle Grace merges with a competing hospital. Meredith, Derek, Izzie, and the rest of the doctors face a brand new challenge with the arrival of doctors from Mercy West. Battle lines are drawn and rivalries reach new heights in an unforgettable year at Seattle Grace.
Season 7[]
Let the healing begin. It's a year of new beginnings for the medical team of Seattle Grace Hospital as they slowly recover from the tragedy that hit too close to home. New relationships emerge and the strongest commitments are tested. From successes in the operating room to mistakes in the bedroom and all the thrilling drama in between the doctors find a way to survive as long as they lean on one another.
Season 8[]
No matter how hot it gets - in the operating room or in the bedroom - the doctors of Seattle Grace know they can always lean on one another. As fifth-year residents, it's do or die for the doctors, and things get bumpy when the chief makes a decision that rocks the entire staff. Outside the hospital, Meredith and Derek struggle to keep their relationship afloat while they try to adopt an orphaned baby girl, and Cristina wrestles with a difficult choice that threatens to ruin her marriage.
Season 9[]
It's a year of bold new beginnings as your favorite doctors return to Seattle Grace for the biggest challenge of their lives. The plane crash that took the lives of Lexie Grey and Mark Sloan sent shockwaves throughout the hospital. But from the ashes, romance will rise, with each surgeon handling the loss in their own personal way. Meredith finds her groove in the operating room while Derek's hand injury forces him to focus on something other than surgery. And as Mark prepares to say goodbye, Alex falls for someone new, Cristina tries to rekindle the flame with Owen, and Bailey and Ben discover the perils of a long-distance relationship.
Season 10[]
The storm may have passed, but now the relationships and romance of Grey Sloan Memorial must survive in its wake. Bonds are tested, love is lost and the hospital bids farewell to Dr. Cristina Yang. Following a massive mudslide, the hospital becomes a madhouse, and the lives of two doctors hang in the balance. The drama escalates as Arizona tries desperately to mend her broken marriage, while Derek and Meredith juggle their roles as surgeons and new parents. Meanwhile, a stunning betrayal pits Cristina against Meredith and, as April prepares for her big day, a familiar face returns to town. Big secrets lead to big problems and turn best friends into rivals.
Season 11[]
It's time to bring the thunder as the doctors of Grey Sloan Memorial face stunning surprises, unprecedented challenges and life changing decisions. Secrets of the past come to light and critical choices shape the future. Relationships are in turmoil as things between Callie and Arizona cool - and Owen and Amelia's romance ignites. April and Jackson face a heartbreaking tragedy.
Meanwhile, Meredith makes a stunning family discovery as opportunities pull Derek further away. And Maggie's shocking announcement proves that blood is thicker than water.
Season 12[]
The doctors find themselves simmering in a world of sexual politics. Bailey struggles with what it means to be a woman in charge of the hospital and her husband, while Maggie faces the challenges of dating a younger man and Amelia battles her own demons. Meanwhile, in the wake of a brutal attack, Meredith finds comfort and love in the most unexpected place, Callie and Arizona find themselves in a fight for their lives, and tensions run high when Amelia and Meredith come face to face with the doctor responsible for Derek's death.
Season 13[]
Performing medical miracles on a daily basis makes the surgeons of Grey Sloan Memorial consider themselves a breed apart from mere mortals. However, what works in the O.R. doesn't always cut it in the "real world." And when the gloves and scrubs come off, they often find that fixing their own chaotic lives takes a lot more than neatly tied sutures.
After being on her own for some time, Meredith is beginning to explore the idea of a romance with Riggs. Unfortunately, Maggie desires him as well, which threatens to drive a bitter wedge between the sisters. At the same time, despite their differences, Jackson and April must come together when they are assigned a difficult case. Meanwhile, Alex faces the consequences of his vicious attack on DeLuca, Owen and Amelia's marriage implodes and a hospital-wide mutiny erupts when Bailey demotes Webber. Finally, Arizona may have found love again - but is she sleeping with the enemy?
Season 14[]
After the fire, Miranda Bailey starts renovations at the hospital. She discovers she'll need more than new walls and paint to repair broken trust, tainted reputations and broken relationships. Against the backdrop of a year full of love, loss and groundbreaking changes, Meredith pioneers a revolutionary surgical technique that earns her a nomination for the coveted award named after its founder, Harper Avery. But when former legend Dr. Avery gets involved in a scandal, Meredith's efforts and the future of Grey Sloan are put in jeopardy.
Season 15[]
Romance is brewing in ways you did not see coming as doctor Teddy Altman is back in an explosive love triangle. And the drama continues as a windstorm blows through Seattle, causing the power to go out at Grey Sloan, leaving the doctors scrambling to save their patients' lives, including Meredith, who desperately needs to get to her patient for her heart transplant.
Season 16[]
TBA
Season 17[]
Grey Sloan Memorial and its surgeons' lives have been turned upside down. It's all-hands-on-deck as Meredith, Bailey and the rest of the Grey Sloan doctors find themselves on the front lines of a new era. Trauma and pressure mount as Koracick is put in charge of the interns. Teddy learns her colleagues know more than she may like about her relationship woes with Owen. And Link accuses Amelia of overstepping while he is treating a patient remotely. Meanwhile, Jackson pays a visit to his father that helps set him on the right path. Maggie and Winston reconnect. And Jo makes a life-changing decision.
Season 18[]
Tensions at Grey Sloan Memorial run high as Owen and Teddy attempt to take the next step in their engagement. Bailey wants to hire new doctors. Richard is reenergised as he takes teaching to a new level at the hospital. Seattle's favorite redhead is back. Levi faces a loss. An explosion rocks Seattle. Jo, Link and Amelia find themselves at a crossroads. And as Meredith struggles with major decisions, she realizes the end of an era is easier said than done.
