Osmosis Jones (2001)

Osmosis Jones is a 2001 American live-action/animated action comedy adventure film with animated scenes

directed by Tom Sito and Piet Kroon and live-action scenes directed by the Farrelly brothers.[3] The film centers on Frank Detorre, a slovenly zookeeper; the live-action scenes are set outside Frank's body, while the animated scenes are set inside his body, which is portrayed as a city inhabited by anthropomorphic blood cells and microorganisms. White blood cell cop Osmosis "Ozzy" Jones and cold pill Drix must prevent deadly virus Thrax from killing Frank within forty-eight hours.

The film was met with mixed reviews, with critics praising the animated portions but criticizing the live-action portions and their use of gross-out humor. The film was also a box office bomb, earning $14 million against a budget of $70 million,[1] though it later sold well in home media. It also served as the pilot to the Kids' WB spin-off television series Ozzy & Drix (2002–04), where Ozzy and Drix get transferred by a mosquito to the body of a teenage boy named Hector and continue their battle against germs and viruses from there.